Advance your research with in situ analysis of cells in their true context
We are amongst the Europe’s first providers for the latest high-plex in situ sequencing solution powered, by 10x Genomic Xenium platform.
Looking to advance your research in cell biology?
Combine the power of single cell & spatial to Advance Your Research
To help you achieve your research and development goals in cell biology, we are equipped with purpose-built single-cell sequencing laboratories, including the latest high-plex in situ sequencing solution powered, by 10x Genomics’ platform Xenium.
Just a 4-hour drive from Munich, Vienna, Milan or Budapest, our research and development laboratory facilities are located at the very centre of Europe, with highly dedicated team of PhD-level scientists.
Moreover, our molecular biology laboratories are equipped and licenced to process samples of biological safety levels I and II and are registered according to the EU regulations for work with Genetically Modified Organisms (GMO) of Biosafety level II (BSL-2).
Our team are dedicated to designing customised solutions to tackle your specific research challenge.
Take your journey with us to help you drive innovation and enable discoveries with our be-spoke high-plex in situ sequencing solution powered by 10x Genomics.
About Xenium technology
Using high-throughput single cell analysis to understand cellular diversity in tissues has opened new avenues of investigation and fueled new discoveries. These insights are only made richer when combined with spatial information. Examining spatial cellular patterns reveals details of the organization of normal and diseased tissue, the immune response and the complex arrangement of neural tissue. Xenium puts this analysis into much-needed context. The Xenium Analyzer instrument is designed for fully automated high-throughput analysis of cells in their tissue environment. Part of an end-to-end solution that includes pre-designed, validated panels and analysis tools for visualizing and studying spatial patterns of expression, the Xenium Analyzer is next-level in situ. Xenium may also be combined with single cell and spatial discovery techniques to bring greater resolution and enable a deeper look into gene expression patterns, helping researchers develop and refine hypotheses.
High throughput
Large imaging areas and multiple slides per run
High resolution
Single cell and subcellular resolution with Z-dimension information
Easy to use
Automated to expand access Intuitive analysis tools
In Situ Analysis
In situ analysis with Xenium detects and preserves the cellular localization of hundreds of RNA targets directly in a tissue section without the need for conventional sequencing. This provides researchers with a detailed map of gene expression patterns without sacrificing resolution of target number.
Visualize & analyze the expression of 1,000s of genes in single cells in their native tissue context from FFPE or FF sections
Have confidence in your data thanks to Xenium’s highly sensitive and specific padlock chemistry
Unite histopathology insights with your high-plex in situ data on the same tissue section
Application and research areas
In situ analysis with Xenium allows researchers to identify gene expression patterns of cells in their original tissues, providing detailed spatial information that will aid research in many application areas, including:
Oncology
Reveal the spatial features of heterogeneity in the tumor and immune microenvironment and identify biomarkers with potential therapeutic impact.
Immunology
Characterize the immune system and spatial localizations in response to infectious disease, allergic inflammation and autoimmune disorders.
Neuroscience
Uncover spatial expression patterns in complex neural tissues in response to disease and traumatic injury.
Technology overview
Xenium in situ analysis uses circulizable probes specific to target transcripts followed by enzymatic amplification to create a target for fluorescent probe hybridization. On the Xenium Analzyer, microscope images of the tissue detect the location of each fluorescent probe, which is then removed. Successive rounds of fluorescent probe hybridization, imaging, and removal produces a unique pattern of on-and-off fluorescent colours in a specific location, creating a unique optical signature that reveals the identity of the RNA at a location within each cell of a tissue. In the future, Xenium will allow the detection of both RNA and protein in the same tissue section, revealing complex and nuanced expression patterns.
Up to 7x faster throughput than other platforms
Immediate access to insights
Xenium Onboard Analysis automatically processes data during a run, without needing to wait for hours of post-run processing. Xenium Explorer, our intuitive visualization software, allows for seamless exploration of your in situ data. Xenium Ranger analysis pipelines give you the flexibility to further refine your data for your research needs, then continue your analysis journey in Xenium Explorer.
Keep full ownership of your data at no extra cost and transfer it from the instrument to the storage location of your choosing.
Visualize an entire unified image with overlaid morphology, segmentation, cell typing, and transcript density at any scale using Xenium Explorer.
Import Xenium data seamlessly into third-party tools for filtering, clustering, trajectory analysis, and beyond without additional processing of the open file formats
Easily reanalyze your data and visualize it in Xenium Explorer thanks to simple data interoperability
Diverse panel menu to fit any research need
Pre-designed Xenium panels
Profile key cell types and states in human or mouse tissues, and customize with up to 100 additional genes
Extensively tested by 10x Genomics on healthy and diseased tissues
Extensively tested by 10x Genomics on healthy and diseased tissues
Ready to ship right away
Custom panels
Select gene markers and signatures of your choosing
Design probes for special applications (isoforms, fusions, viral/bacterial sequences, protein tags, and fluorescent reporters)
Designed and delivered in 4–6 weeks
Labena’s Research & Development Laboratories
A Comprehensive set of Research & Development & Analytics services
We are a family-owned business, with almost 30 years of experience working in tandem with global pharmaceutical and biopharmaceutical companies, research institutes and academia. We support our customers in research and development, manufacturing, and analytics. Our facilities are also GMP certified and are regularly inspected by FDA and EMA.
We work with you Responsively, as if you were one of us.
As a family business, we place qualit and excellence of services we provide to our partners front and centre. We have vast experience in working with highly regulated sectors and partners that uphold highest standards of quality in their research and development processes, analytics and manufacturing – such as research and development centres, institutions, clinical research institutions focused on translational research, academia and pharmaceutical and biopharmaceutical manufacturers- Our in-lab processes in analytics are GMP certified, and regularly inspected by EMA and FDA, whilst in our Research and Development laboratories we abide by GMP-like standards and processes, holding up to the highest quality standards and procedures.
We provide On Point solutions.
Quality of our services, solutions, and satisfaction of our partners are of utmost importance to us. As such, we take a customised approach to every partner. Our team will work closely with you, providing guidance and support throughout your collaboration with us. We are committed to maintaining a high-touch, collaborative relationship with our partners at all times.
